Decreased appetite can result from infections, emotional stress, or medication side effects. Acute illnesses such as influenza or gastrointestinal infections often suppress hunger due to inflammatory cytokine release.

Chronic diseases including cancer, liver disorders, and thyroid dysfunction may also impair appetite regulation. Psychological conditions like depression and anxiety frequently alter hypothalamic signaling, reducing food intake.

Certain antibiotics, including cephalexin, may cause nausea or gastrointestinal discomfort, indirectly lowering appetite; this is relevant in pharmaceutical supply discussions involving cephalexin capsules wholesale distribution.

Additionally, aging, hormonal imbalance, chronic pain, and digestive disorders can contribute. Persistent appetite loss warrants medical evaluation to exclude underlying pathology and nutritional deficiency.